Case of Cladophialophora caroinii Chromoblastomycosis

Case of Cladophialophora caroinii Chromoblastomycosis A Rare Case of Cladophialophora caroinii Chromoblastomycosis in a Skin Graft Recipient Roy PK, Dudhat VL, Prasanna S Introduction: Chromoblastomycosis, also called chromomycosis is a subcutaneous chronic mycosis caused by dematiaceous (black) fungi.1 The most frequently isolated organisms are Fonsecaea pedrosoi, Phialophora. verrucosa, Cladosporium carrioni, and less frequently, Rhinocladiella aquaspersa.2 It Progresses slowly and involves exposed body parts. It is characterised by crusted and raised lesions. The fungi present as sclerotic bodies in the lesions, which is a pathognomic feature of this disease. It is distributed worldwide. However it is most commonly seen in tropical and subtropical regions.1 C. caroinii has been reported only sporadically in India in a few case reports.3,4,5,6,7 We present a rare case of chromoblastomycosis by C. caroinii. Case Description: A 40 year old male patient, presented to the surgery OPD with cutaneous ulcer over right knee after a fall injury, not associated with fever or pain. The patient was admitted in a tertiary care centre, I.V antibiotics and daily dressing had been done. The swabs from the base of the ulcer had been sent for bacterial culture and sensitivity, shown no growth. After a few days of treatment ulcer was healing with good margins and base. Patient was discharged with oral antibiotics and anti-inflammatory agents. After one month patient came back for review to OPD with hypopigmented patch over the right knee. The patient was referred to plastic surgery department and skin grafting was done. The graft was taken from the right back. The patient was administered with I.V steroids, antibiotics and oral anti-inflammatory agents. The patient was discharged with oral steroids with tapering dose and antibiotics. After two weeks period, patient developed soft non-raised fluctuating swelling post skin grafting over the same region (right knee). Differential diagnosis of cutaneous tuberculosis and aspergilloma was made. The FNAC was carried out from the swelling, from which frank pus was aspirated. The pus sample was forwarded for bacterial culture, fungal and mycobacterial culture. The bacterial cultures, both aerobically and anaerobically showed no growth. The sample was negative for acid fast bacilli by Ziehl Neelsen staining. However, KOH mount and Gomori’s methenamine silver (GMS) stain showed septate hyaline hyphae. The GMS stain revealed few grey black round structures measuring around 6-10 Â µm, suggestive of Medlar or sclerotic or copper penny bodies. The culture of the pus sample, on Lowenstein-Jensen medium showed no growth after eight weeks of incubation. However, culture on Sabouraud dextrose agar with chloramphenicol revealed slow growing fungus, which was first observed on the tenth day and gradually matured over next three weeks. The growth was initially grey-green which slowly turned to olive-green with cottony folded out texture and with a jet black reverse after three weeks of incubation at 25Â °C. The lacto phenol cotton blue (LPCB) preparation, from the culture showed septate hyaline hyphae with acropetal long chains of conidia suggestive of Chladophialophora species. The fungus showed growth at 37Â °C, but not at 42-45Â °C and urease negative. Based on these findings the fungus was identified as Chladophialophora carrionii. The patient was diagnosed to have subcutaneous mycosis (chromoblastomycosis) with the presence of sclerotic bodies and the causative organism was identified as Chladophialophora carrionii. The patient was started on oral Itraconazole and he showed good improvement in the condition. Discussion: As first described by Medlar in 1915, the term chromoblastomycosis is used for cases in which sclerotic bodies are present in tissue. Sclerotic bodies, also known as Medlar bodies, are globe-shaped, cigar-colored, thick-walled structures that are 4-12 Â µm in diameter.8 The best name to define the disease was recommended as chromoblastomycosis by the International Society for Human and Animal Mycology (ISHAM).9 The term chromoblastomycosis (chromo – coloured, blasto – budding, mycosis – fungal) was coined by Terra et al in 1922 to define a polymorphic fungal disease located on lower limbs, consisting of nodular or verrucous plaques which could probably ulcerate and develop into hyperkeratosis and acanthosis of the affected epithelial tissues.10 This condition is often misdiagnosed as it is clinically indistinguishable from tuberculosis verrucosa cutis, squamous cell carcinoma, palmo-plantar psoriasis, and sporotrichosis.11,12,13 In this case also, a differential diagnosis of cutaneous tuberculosis was kept in mind. The typical histopathological findings of cutaneous chromoblastomycosis are marked epitheliomatous hyperplasia, microabscesses, chronic granulomatous infiltrates with multinucleate giant cells, epithelioid cells, histiocytes and lymphocytes and presence of copper penny bodies.14 in this case we found septate hyphae and sclerotic bodies on GMS stain of FNAC sample. Certain non-pathogenic or contaminant fungi such as Paecilomyces spp and Penicillium spp. may be sometimes confused with Cladophialophora carrionii. Although both these fungi produce long chains of elliptical conidia, the conidia arise from structures such as metula and phialides, which are not seen in C. carrionii. Both these fungi are rapid growers, unlike C. carrionii, which grows very slowly. Moreover, these non-pathogenic fungi usually form greenish white or greenish brown colonies with no pigment on the reverse, in contrast to the jet black reverse of C. carrioni i, which helps in correct identification of this fungi.15 However, C. carrionii should be differentiated from other similar dematiaceous fungi such as Cladophialophora bantiana and Fonsecaea pedrosoi. C. bantiana has the ability to grow at 42-43Â °C, which can be used to differentiate it from C.carrionii. Unlike Cladophialophora spp., Fonsecaea spp. produce short chains of five or less conidia. Moreover, in Fonsecaea spp. At least two of the three types of anamorphic conidiation (rhinocladiella, phialophora, cladosporium) will be seen.15 Slide culture technique will be useful for proper identification of the above-mentioned features.15 Surgery was considered the treatment of choice for chromoblastomycosis before the advent of triazole antifungal agents.16 However, currently with the availability of potent antifungal agents, chemotherapy has become the first-line of treatment with itraconazole and terbinafine being the drugs of choice, while surgery is used only for limited or small lesions.17 As there have been only few and sporadic case reports of chromoblastomycosis caused by C. caroinii from India, this case reports finds its importance.3,4,5,6,7 References: Kalabhavi AS. Chromoblastomycosis – Review article. International Journal of Current Research 2013: 5(7);1691-5 Silva JP, de Souza W, Rozental S. Chromoblastomycosis: a retrospective study of 325 cases on Amazonic Region (Brazil). Mycopathologia 1998-1999;143:171-5. Pradeepkumar NS, Joseph NM. Chromoblastomycosis caused by Cladophialophora carrionii in a child from India. J Infect Dev Ctries 2011; 5(7):556-560. APTE G, GEDAM JR, POOJARY S, GURU N, PAI VV. Chromoblastomycosis in a case of borderline lepromatous leprosy with recurrent Type II lepra reaction. Lepr Rev (2011) 82, 310–5 Shanthala GB, Rudresh SM, Nagarathnamma T. Chromoblastomycosis: A Case Report. Journal of Clinical and Diagnostic Research 2011:5(4); 865-6 Mandal RK, Banerjee S, Kumar P, Chakrabarti I. Non-healing verrucous plaque over upper limb for 1 year in a tea garden worker. Dermatology Online Journal 19 (3): 12 Kindo AJ, Ramalakshmi S, Giri S, Abraham G. A Fatal Case of Prostatic Abscess in a Post-Renal Transplant Recipient Caused by Cladophialophora carrionii. Saudi J Kidney Dis Transpl 2013;24(1):76-9 Medlar EM. A cutaneous infection caused by a new fungus Phialophora verrucosa with a study of the fungus. J Med Res. 1915; 32:507-22. Odds FC, Arai T, Disalvo AF, et al. Nomenclature of fungal diseases: a report and recommendations from a Sub-Committee of the International Society for Human and Animal Mycology (ISHAM). J Med Vet Mycol. 1992; 30(1):1-10. Terra F, Torres M, Fonseca Filho O. Novo tipo de dermatite verrucosa; micose por Acrotheca com associado de leishmaniose. Brasil Medico. 1922; 36:363-8. Pradhan SV, Talwar OP, Ghosh A, Swami RM, Shiva Raj KC, Gupta S. Chromoblastomycosis in Nepal: a study of 13 cases. Indian J Dermatol Venereol Leprol 2007: 73; 176-8 Mohanty L, Mohanty P, Padhi T, Samantray S. Verrucous growth on leg. Indian J Dermatol Venereol Leprol2006: 72; 399-400. Nair PS, Sarojini PA. Chromoblastomycosis resembling sporotrichosis. Indian J Dermatol Venereol Leprol 1993: 59; 125-6. Nirmala V, Chacko CJ, Job CK. Tuberculoid leprosy and tuberculosis skin: a comparative histopathological study. Lepr India 1977: 49; 65-9 Fisher F, Cook NB. Fundamentals of Diagnostic Mycology. Philadelphia: W.B.Saunders Company 1998; 372 Sayal SK, Prasad GK, Jawed KZ, Sanghi S, Satyanarayana S. Chromoblastomycosis. Indian J Dermatol Venereol Leprol 2002:68; 233-4. Gupta AK, Taborda PR, Sanzovo AD. Alternate week and combination itraconazole and terbinafine therapy for chromoblastomycosis caused by Fonsecaea pedrosoi in Brazil. Med Mycol 2002:40; 529-534

Criminal Liability Essay

In law there is a fundamental principle which is guaranteed by the constitution that every person is innocent until proven to be guilty by the courts of law, in criminal law there are two principles of criminal liability which have to be relied upon in order to determine the guilt or innocence of the accused person. Therefore the aim of this essay is to discuss the two principles of law for criminal liability with reference to the Penal Code Act, Chapter Eighty Seven (87) of the Laws of Zambia and Zambian decided cases. In order to effectively do this, the essay will begin by generally talking about the two principles of law for criminal liability which are the â€Å"Actus reus† and the â€Å"mens rea† and in order to critically discuss them, focus will be made on the Homicide offence of ‘murder’ with the use of relevant Zambian cases. The terms ‘Actus reus’ and ‘Mens rea’ are derived from the Latin Maxim; â€Å"Actus non facit re um mens sit rea† which mean that there cannot be such a thing as legal guilt where there is no moral guilt. The learned author Simon E Kulusika defines ‘Actus reus’ as â€Å"whatever act or omission or state of affairs as laid down in the definition of the particular crime charged in addition to any surrounding circumstances†¦and the ‘mens rea’ as the state of mind or fault which is required in the definition of the crime in question† In order for a person to be criminally liable it has to be proved by the prosecution beyond reasonable doubt that such a person had committed the required guilty act or ‘actus reus’ which is the physical element and had the necessary mental state or ‘mens rea’ although this is not always the case as some criminal offences do not require the ‘mens rea’ for liability to be established. Some of the cases which do not require establishment of the ‘mens rea’ are offences referred to as â€Å"offences of strict liability†. In Patel’s Bazaar limited v The People4 it was stated that proof of the ‘mens rea’ is not necessary to establish a strict liability offence, this was a case in which the accused was convicted for the strict liability offence of selling unwholesome bread. Generally speaking in criminal law in order to establish criminal liability certain elements of the crime alleged to have been committed must be identified, the first being the conduct prohibited or ‘actus reus’, secondly the state of mind or fault element which is required when defining the crime in question also referred to as ‘mens rea’ and thirdly proof of lack of a defence which might vitiate any of the two  principles of criminal liability. As earlier alluded to, for the purposes of this assignment focus will be put on the homi cide offence of Murder in trying to discuss these two principles of law of criminal liability. To establish the ‘actus reus’ of murder it has to be proved that there is unlawful killing of a person, the death following within a day and a year of the infliction of the fatal injury,  this is evident in Section 200 of our Penal Code Act 6 which provides; Any person who of malice aforethought causes the death of another person by an unlawful act or omission is guilty of murder. In this section the ‘actus reus’ is identified as causing death of another person by an unlawful act or omission and the ‘mens rea’ is the malice aforethought. In Chitenge v The People it was held that the actus reus of murder is that there is a dead body, in this case the appellant having had fought with his friend went to the friend’s house and set it on fire burning a person that was inside leading to the death of that person. The dead burnt body sufficed as ‘actus reus’ despite the defendant not actually having had checked as to whether there was a person in the house or not. Coming to the ‘mens rea’, the requirement is that the accused person must have malice aforethought. The term malice aforethought is used to describe the mens rea of murder and it simply means that the mens rea must not come as an afterthought. In the case of Mbomena Moola v the people, the appellant was convicted of murder of his father after he poisoned his maheu drink. In his confession the appellant stated that he poisoned his father so that he could die because he believed that he was the one who bewitched his children. In this case the courts held that it was quiet clear that the accused had the necessary mens rea for murder as he expressly intended on causing death of his victim. Taking into consideration the facts given in the question where the accused is charged with murder in which the mens rea is that the accused must be malice aforethought and the actus reus being the death which is satisfactory in this case, it is worth noting that where offences complained of happened during participation in a sport, the accused cannot be held to be criminally liable as in law it is believed that when participants to a sporting game give consent they do so to all the risks of injury that may take place as a result of accidents that may take place during the sport including death. Therefore applying the two principles of law of criminal liability to the given facts it can be stated that though  the actus reus was present, that is the death of Mr Mudenda, Mr Chisolo lacked the necessary mens rea to be convicted for murder and can also not be convicted of manslaughter due to the fact that the death or actus reus was as a result of an accident in a sport of which consent by the participants vitiates criminal liability. In conclusion it can be stated that this essay has identified two principles of law of criminal liability which are the ‘actus reus’ and the ‘mens rea’. It has being discussed that the ‘actus reus’ refers to whatever act or omission or state of affairs as laid down in the definition of the particular crime charged in addition to any surrounding circumstances and an example was given in the offence of murder. The ‘mens rea’ with reference to murder was also discussed as the state of mind or fault which is required in the definition of the crime in question and that criminal liability cannot be inferred if the offence complained of took place during the occurrence of a sport as consent vitiates it. BIBLIOGRAPHY BOOKS Kulusika S. E, Criminal law in Zambia; text, cases and materials: UNZA press. Lusaka. 2006 Sir Smith J and Hogan B, Criminal law; Cases and materials, sixth edition: Dublin & Edinburgh. Butterworth. 1996 CASES Chitenge v the people (1996) ZR 37 Mbomena Moola v the people (2000) ZR 148 SC STATUTES The Penal Code Act, Chapter 87 of the laws of Zambia.

Criminal Liability Essay

In law there is a fundamental principle which is guaranteed by the constitution that every person is innocent until proven to be guilty by the courts of law, in criminal law there are two principles of criminal liability which have to be relied upon in order to determine the guilt or innocence of the accused person. Therefore the aim of this essay is to discuss the two principles of law for criminal liability with reference to the Penal Code Act, Chapter Eighty Seven (87) of the Laws of Zambia and Zambian decided cases. In order to effectively do this, the essay will begin by generally talking about the two principles of law for criminal liability which are the â€Å"Actus reus† and the â€Å"mens rea† and in order to critically discuss them, focus will be made on the Homicide offence of ‘murder’ with the use of relevant Zambian cases. The terms ‘Actus reus’ and ‘Mens rea’ are derived from the Latin Maxim; â€Å"Actus non facit re um mens sit rea† which mean that there cannot be such a thing as legal guilt where there is no moral guilt. The learned author Simon E Kulusika defines ‘Actus reus’ as â€Å"whatever act or omission or state of affairs as laid down in the definition of the particular crime charged in addition to any surrounding circumstances†¦and the ‘mens rea’ as the state of mind or fault which is required in the definition of the crime in question† In order for a person to be criminally liable it has to be proved by the prosecution beyond reasonable doubt that such a person had committed the required guilty act or ‘actus reus’ which is the physical element and had the necessary mental state or ‘mens rea’ although this is not always the case as some criminal offences do not require the ‘mens rea’ for liability to be established. Some of the cases which do not require establishment of the ‘mens rea’ are offences referred to as â€Å"offences of strict liability†. In Patel’s Bazaar limited v The People4 it was stated that proof of the ‘mens rea’ is not necessary to establish a strict liability offence, this was a case in which the accused was convicted for the strict liability offence of selling unwholesome bread. Generally speaking in criminal law in order to establish criminal liability certain elements of the crime alleged to have been committed must be identified, the first being the conduct prohibited or ‘actus reus’, secondly the state of mind or fault element which is required when defining the crime in question also referred to as ‘mens rea’ and thirdly proof of lack of a defence which might vitiate any of the two  principles of criminal liability. As earlier alluded to, for the purposes of this assignment focus will be put on the homi cide offence of Murder in trying to discuss these two principles of law of criminal liability. To establish the ‘actus reus’ of murder it has to be proved that there is unlawful killing of a person, the death following within a day and a year of the infliction of the fatal injury,  this is evident in Section 200 of our Penal Code Act 6 which provides; Any person who of malice aforethought causes the death of another person by an unlawful act or omission is guilty of murder. In this section the ‘actus reus’ is identified as causing death of another person by an unlawful act or omission and the ‘mens rea’ is the malice aforethought. In Chitenge v The People it was held that the actus reus of murder is that there is a dead body, in this case the appellant having had fought with his friend went to the friend’s house and set it on fire burning a person that was inside leading to the death of that person. The dead burnt body sufficed as ‘actus reus’ despite the defendant not actually having had checked as to whether there was a person in the house or not. Coming to the ‘mens rea’, the requirement is that the accused person must have malice aforethought. The term malice aforethought is used to describe the mens rea of murder and it simply means that the mens rea must not come as an afterthought. In the case of Mbomena Moola v the people, the appellant was convicted of murder of his father after he poisoned his maheu drink. In his confession the appellant stated that he poisoned his father so that he could die because he believed that he was the one who bewitched his children. In this case the courts held that it was quiet clear that the accused had the necessary mens rea for murder as he expressly intended on causing death of his victim. Taking into consideration the facts given in the question where the accused is charged with murder in which the mens rea is that the accused must be malice aforethought and the actus reus being the death which is satisfactory in this case, it is worth noting that where offences complained of happened during participation in a sport, the accused cannot be held to be criminally liable as in law it is believed that when participants to a sporting game give consent they do so to all the risks of injury that may take place as a result of accidents that may take place during the sport including death. Therefore applying the two principles of law of criminal liability to the given facts it can be stated that though  the actus reus was present, that is the death of Mr Mudenda, Mr Chisolo lacked the necessary mens rea to be convicted for murder and can also not be convicted of manslaughter due to the fact that the death or actus reus was as a result of an accident in a sport of which consent by the participants vitiates criminal liability. In conclusion it can be stated that this essay has identified two principles of law of criminal liability which are the ‘actus reus’ and the ‘mens rea’. It has being discussed that the ‘actus reus’ refers to whatever act or omission or state of affairs as laid down in the definition of the particular crime charged in addition to any surrounding circumstances and an example was given in the offence of murder. The ‘mens rea’ with reference to murder was also discussed as the state of mind or fault which is required in the definition of the crime in question and that criminal liability cannot be inferred if the offence complained of took place during the occurrence of a sport as consent vitiates it. BIBLIOGRAPHY BOOKS Kulusika S. E, Criminal law in Zambia; text, cases and materials: UNZA press. Lusaka. 2006 Sir Smith J and Hogan B, Criminal law; Cases and materials, sixth edition: Dublin & Edinburgh. Butterworth. 1996 CASES Chitenge v the people (1996) ZR 37 Mbomena Moola v the people (2000) ZR 148 SC STATUTES The Penal Code Act, Chapter 87 of the laws of Zambia.

Criminal Liability Essay

In law there is a fundamental principle which is guaranteed by the constitution that every person is innocent until proven to be guilty by the courts of law, in criminal law there are two principles of criminal liability which have to be relied upon in order to determine the guilt or innocence of the accused person. Therefore the aim of this essay is to discuss the two principles of law for criminal liability with reference to the Penal Code Act, Chapter Eighty Seven (87) of the Laws of Zambia and Zambian decided cases. In order to effectively do this, the essay will begin by generally talking about the two principles of law for criminal liability which are the â€Å"Actus reus† and the â€Å"mens rea† and in order to critically discuss them, focus will be made on the Homicide offence of ‘murder’ with the use of relevant Zambian cases. The terms ‘Actus reus’ and ‘Mens rea’ are derived from the Latin Maxim; â€Å"Actus non facit re um mens sit rea† which mean that there cannot be such a thing as legal guilt where there is no moral guilt. The learned author Simon E Kulusika defines ‘Actus reus’ as â€Å"whatever act or omission or state of affairs as laid down in the definition of the particular crime charged in addition to any surrounding circumstances†¦and the ‘mens rea’ as the state of mind or fault which is required in the definition of the crime in question† In order for a person to be criminally liable it has to be proved by the prosecution beyond reasonable doubt that such a person had committed the required guilty act or ‘actus reus’ which is the physical element and had the necessary mental state or ‘mens rea’ although this is not always the case as some criminal offences do not require the ‘mens rea’ for liability to be established. Some of the cases which do not require establishment of the ‘mens rea’ are offences referred to as â€Å"offences of strict liability†. In Patel’s Bazaar limited v The People4 it was stated that proof of the ‘mens rea’ is not necessary to establish a strict liability offence, this was a case in which the accused was convicted for the strict liability offence of selling unwholesome bread. Generally speaking in criminal law in order to establish criminal liability certain elements of the crime alleged to have been committed must be identified, the first being the conduct prohibited or ‘actus reus’, secondly the state of mind or fault element which is required when defining the crime in question also referred to as ‘mens rea’ and thirdly proof of lack of a defence which might vitiate any of the two  principles of criminal liability. As earlier alluded to, for the purposes of this assignment focus will be put on the homi cide offence of Murder in trying to discuss these two principles of law of criminal liability. To establish the ‘actus reus’ of murder it has to be proved that there is unlawful killing of a person, the death following within a day and a year of the infliction of the fatal injury,  this is evident in Section 200 of our Penal Code Act 6 which provides; Any person who of malice aforethought causes the death of another person by an unlawful act or omission is guilty of murder. In this section the ‘actus reus’ is identified as causing death of another person by an unlawful act or omission and the ‘mens rea’ is the malice aforethought. In Chitenge v The People it was held that the actus reus of murder is that there is a dead body, in this case the appellant having had fought with his friend went to the friend’s house and set it on fire burning a person that was inside leading to the death of that person. The dead burnt body sufficed as ‘actus reus’ despite the defendant not actually having had checked as to whether there was a person in the house or not. Coming to the ‘mens rea’, the requirement is that the accused person must have malice aforethought. The term malice aforethought is used to describe the mens rea of murder and it simply means that the mens rea must not come as an afterthought. In the case of Mbomena Moola v the people, the appellant was convicted of murder of his father after he poisoned his maheu drink. In his confession the appellant stated that he poisoned his father so that he could die because he believed that he was the one who bewitched his children. In this case the courts held that it was quiet clear that the accused had the necessary mens rea for murder as he expressly intended on causing death of his victim. Taking into consideration the facts given in the question where the accused is charged with murder in which the mens rea is that the accused must be malice aforethought and the actus reus being the death which is satisfactory in this case, it is worth noting that where offences complained of happened during participation in a sport, the accused cannot be held to be criminally liable as in law it is believed that when participants to a sporting game give consent they do so to all the risks of injury that may take place as a result of accidents that may take place during the sport including death. Therefore applying the two principles of law of criminal liability to the given facts it can be stated that though  the actus reus was present, that is the death of Mr Mudenda, Mr Chisolo lacked the necessary mens rea to be convicted for murder and can also not be convicted of manslaughter due to the fact that the death or actus reus was as a result of an accident in a sport of which consent by the participants vitiates criminal liability. In conclusion it can be stated that this essay has identified two principles of law of criminal liability which are the ‘actus reus’ and the ‘mens rea’. It has being discussed that the ‘actus reus’ refers to whatever act or omission or state of affairs as laid down in the definition of the particular crime charged in addition to any surrounding circumstances and an example was given in the offence of murder. The ‘mens rea’ with reference to murder was also discussed as the state of mind or fault which is required in the definition of the crime in question and that criminal liability cannot be inferred if the offence complained of took place during the occurrence of a sport as consent vitiates it. BIBLIOGRAPHY BOOKS Kulusika S. E, Criminal law in Zambia; text, cases and materials: UNZA press. Lusaka. 2006 Sir Smith J and Hogan B, Criminal law; Cases and materials, sixth edition: Dublin & Edinburgh. Butterworth. 1996 CASES Chitenge v the people (1996) ZR 37 Mbomena Moola v the people (2000) ZR 148 SC STATUTES The Penal Code Act, Chapter 87 of the laws of Zambia.

Edgar Allan Poe s Life - 1092 Words

Edgar Allan Poe lived in a constant state of struggle and misfortune. Poe was raised with no father, while his mother suffered from tuberculosis for the first three years of his life. Following the death of his mother, a young Poe moved into the house of John and Frances Allan. In his lifetime, Poe attended the University of Virginia for one semester, The United States Military Academy at West Point and enlisted in the military under an alias of â€Å"Edgar A. Perry.† (Ober, 1960) After constantly being unhappy with his choices, Poe left the military along with West Point. Shortly after leaving, Poe married his younger cousin, Virginia. After the death of Virginia, Poe became engaged to his childhood sweetheart, Sarah Elmira Royster Shelton. Poe lived for only forty years, in these forty years he never saw success, could not stay in school and had mental issues that have still not been fully comprehended to this day. His poems and short stories have set a foundation for count less writers. Scholars have analyzed Poe’s works, each clearly stating his insanity, while some said he was murderous. While I do not believe Poe was a murderer, there were clearly mental issues beyond comprehension. Poe’s works are still being sold, ironically they were not popular until after his death. This author created the foundation in which some authors have taken an interest to. Before Poe, there were few mystery tales. I believe that Poe has influenced writers, for example, H.P Lovecraft. BornShow MoreRelatedThe Life Of Edgar Allan Poe s Life994 Words   |  4 PagesThe Life of Edgar Allan Poe Edgar Allan Poe was born January 9th ,1809 in Boston, Massachusetts. He experienced death at a very early age. By the time he was three both of his parents were dead. He then got placed with foster parents John and Frances Allan. John Allan was a very wealthy man and sent Edgar to all the best boarding schools. After finishing school Edgar attended the University of Virginia. He was great in school, but unfortunately, he had to leave due to his many gambling debts. HeRead MoreAn Analysis Of Edgar Allan Poe s Life1497 Words   |  6 Pageswith an Author Framework Edgar Allan Poe was born in Boston, on January 19th, 1809 and was best known as a writer of dark poetry and short stories. Poe had an interesting and somewhat tragic upbringing , he was orphaned as a young child and then raised by an affluent couple called John and Frances Allan from Richmond, Virginia. Poe spent 5 years in England as a young child and studied different languages , however his universityRead MoreEdgar Allan Poe s Life And Experiences2032 Words   |  9 Pages Edgar Allan Poe: For Better Or Worse All great writers write about what they know and experience. It may be on purpose or subconscious, but it can be seen in their writing with such things as places, people, and ideals. With the great Edgar Allan Poe, it is clear that he continually wrote about his life and experiences. Edgar Allan Poe’s issues with alcoholism, the loss of loved ones, and issues with himself can be seen in his characters and themes throughout his writing. Poe had issues with alcoholismRead MoreEdgar Allan Poe s Life1308 Words   |  6 PagesPoe was born on January 19, 1809. Poe was born into a family that was high respected and very public, so Poe was destined to have a public career (Dameron and Jacobs). When Poe was two, his parents died (â€Å"Edgar Allan Poe†) and his remaining family was split up into three different foster parents/homes. His oldest brother, William, lived with Poe’s grandfather from his father’s side of the family. Poe’s youngest sibling, Rosalie, lived with William Mackenzie. Poe went with John Allan whose wife wasRead MoreEdgar Allan Poe s `` Rough Early Life ``1108 Words   |  5 PagesFebruary 2017 Edgar Allan Poe Have you ever wondered the reasons behind why some horror stories are so sinister? Have you ever read a horror story and told yourself that it would not happen in real life? Have your ever thought that you had a rough life growing up? Poe did not live to see his name really get the big praise it does now for his horror. Most of Poe’s life was filled with death of loved one’s and sadness which made him turn to writing poems and short stories. Edgar Allan Poe’s rough earlyRead MoreThe Life Of Edgar Allan Poe s Life Of Despair900 Words   |  4 PagesA Life of Despair: The Life of Edgar Allan Poe Edgar Poe was born on January 19, 1809 in Boston, Massachusetts to parents, David and Elizabeth Arnold Poe, both were actors. David Poe, who died shortly after, abandoned the family before Poe was two years old, leaving his mother alone with the three kids. Not too long after, Poe watched as his mother slowly died of Tuberculosis, while coughing up blood. Unfortunately for Poe, this was just the beginning of a life full of despair. Though he was neverRead MoreEdgar Allan Poe s Life And The Way1453 Words   |  6 Pagesperson that I choose to write about is Edgar Allan Poe. I choose Edgar Allan Poe because he is widely acknowledgeable as the inventor of the modern detective story and an innovator when it comes to the science fiction category. The reason I picked Poe is because I like the way he writes and how it’s kind of spooky and mysterious his poems and short stories The time period Edgar Allan Poe lived in affected his life and the way he wrote literature. When Poe first started out he was living as America’sRead MoreAnalysis Of Edgar Allan Poe s Life1954 Words   |  8 PagesThroughout the many works that Edgar Allan Poe has written in his lifetime, whether the work is a poem, novel, analysis, or critique, Poe has incorporated many reoccurring themes that define him as a writer. A theme that has brought much criticism upon Poe is his Classicist aspect of writing. Poe was very clear and detailed when he wrote in prose. This way of writing proved him to be somewhat of a rebel and veered off the beaten path when it comes to form. In Poe’s time the Gothic style was notRead MoreEdgar Allan Poe s Life Filled With Sorrow And Pain892 Words   |  4 PagesThesis: Edgar Allan Poe led a life filled with sorrow and pain. His works tend to reflect his lifestyle by incorporating darker elements in the usage of his characters. Edgar Allan Poe was born January 19, 1809 to two actors, David Poe Jr. and Elizabeth Arnold Hopkins Poe. He was born in Boston. Before he was three years old, his father abandoned him, his brother (William Poe), and his sister (Rosalie Poe). Shortly after this, his mother died, leaving the three children orphaned. Poe moved to BostonRead MoreAn Analysis Of Edgar Allan Poe s The Black Cat 1650 Words   |  7 PagesBrittany White Mrs. Bey English 1101 1 April 2015 A Day in the Life Edgar Allan Poe is a very talked about writer. He has a dark, mysterious, gothic writing style. Poe was a troubled man that struggled in a lot of different areas in his life. It is believed that all of Edgar Allan Poe’s short stories were connected to his tragic life events. â€Å"The Black Cat† is one of Edgar’s well-known short stories. It is about a man that endured a series of tragic events. This man was very feminine and his lack

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No Pains No Gains Distributed Database Solutions

NO PAINS NO GAINS: DISTRIBUTED DATABASE SOLUTIONS CSC 633 RAJEEV SAGAR REDDY MERUGU. INTRODUCTION: Database management has undergone more than four decades of evolution producing vast range of research and extensive array of technology solutions. The database research community and software industry has responded to numerous challenges resulting from changes in user requirements and opportunities presented by hardware advances. The relational database approach as represented by SQL databases has been particularly successful and one of the most durable paradigms in computing. Most recent database challenges include internet-scale databases – databases that manage hundreds of millions of users and cloud databases that use novel techniques†¦show more content†¦RDBMS stores the data in the form of tables and can be retrieved from the tables with the help of SQL Language. SQL was invented only after the invention of RDBMS. SQL – Sequential Query Language. Most common RDBMS’s are My SQL, DB2, Oracle, and Microsoft SQL. The reason for using RDBMS rather than a DBMS is that DBMS stores data in the form of Files whereas RDBMS stores data in the form of Tables containing rows and columns and there exists a primary key relationship such that the data stored in multiple tables can be retrieved using SQL. As RDBMS is a relational database model, the data is stored in the tables in the form of relations. RDBMS supports Distributed database and is designed to handle large amounts of data. Database research and associated standardization activities have successfully guided the development of database technology over the last four decades and SQL relational databases remain the dominant database technology today. This effort to innovate relational databases to address the needs of new applications is continuing today. Recent examples of database innovation include the development of streaming SQL technology that is 170 George Feuerlicht used to process rapidly flowing data (â€Å"data in flight†) minimizing latency in Web 2.0 applications, and database appliances that simplify DBMS deployment on cloud computing platforms. It is also evident from the above discussion that the relationalShow MoreRelatedCisco System Case Study1510 Words   |  7 PagesFinance and Order Entry system corrupted the core application database malfunctioning of the system and cisco was shut down for 2 days virtually. This moment has made management to take critical decisions on their IT system. Cisco decided to have a single integrated solution for all the 3 functional areas and with help of KPMG as an integration partner, Cisco has selected Oracle ERP product as their IT solution partner and deployed solution in production by Jan 1995. Also, by 2001, Cisco has successfullyRead MoreNew Pains, New Gains3369 Words   |  14 PagesNew Pains, New Gains: Distributed Database Solutions are on their way D atabase is a collection of data which describes the activities of one or more organizations in a well-defined structure and the structure of a database is specific and it has a purpose. Database Management System (DBMS) is used to control or organize the data in a database. Database Management System (DBMS) is also used for maintaining large collections of data. Distributed database can be defined as a collection of variousRead MoreWhat s The Real Role Of Your Network?1967 Words   |  8 PagesApplications Are Performing Increase productivity by implementing more robust application monitoring [p. 1: Introduction] Corporate networks are facing an unprecedented number of challenges, from ensuring data security to increasing mobility across a distributed workforce. As IT manages all the components of network performance, like storage, switches, servers and firewall, there s a need to take a deeper dive into the question: What s the real role of your network? For most, if not all, businesses inRead MoreSupply Chain Business Intelligence Technologies, Issues and Trends9649 Words   |  39 Pagesservices. Many companies are beginning their search for a solution to implementing an electronically oriented supply chain management system that provides connection to customers and to suppliers. This integrated supply chain may be based on new M. Bramer (Ed.): Artificial Intelligence, LNAI 5640, pp. 217 – 245, 2009.  © IFIP International Federation for Information Processing 2009 218 N. Stefanovic and D. Stefanovic software solutions or based on enhanced communication capabilities. The ultimateRead MoreConstructing the Written Evidence-Based Proposal: Patient Quality Service When Dealing with Urinary Tract Infections5418 Words   |  22 Pagesincorporated, solution identification, incorporating a theory, implementation plan, evaluation plan, dissemination of results Literature Review. The main focus of the paper is the patient quality service when dealing with urinary tract infections (UTI), catheter-associated urinary tract infections (CAUTIs). UTI is an infection of the urethra, bladder, ureters and kidneys that occurs when bacteria gain access to the urinary system. This infects the urine of the patients and leads to pain in the lowerRead MoreThe Problem Of Organ Trafficking2906 Words   |  12 Pagesboth children and adults are victims of organ trafficking. Those who have their organs unwillingly removed and sold are likely to also be victims of human trafficking. Many of these people ar e lured in with promises of a â€Å"better life† or monetary gain, more often than not these are empty promises that result in dangerous situations. Within the black-market trade of organs, also referred to as the â€Å"red-market†, the amount of money or even the sales of these organs are also effected by the culturalRead MoreDo-Not-Resuscitate: Legal and Ethical Issues Essay3308 Words   |  14 Pagespopular subject of many fictional books. However, as technology evolves and the story of Frankenstein reborn with a bolt of lighting has come true with the external or implanted defibrillators, the natural process of death slows as much of society gains the knowledge to live longer than nature intended. The Red Cross Association taught many organizations like the girl and boy scouts the methods of mouth-to-mouth resuscitation and Cardiopulmonary resuscitation or CPR, a manual manipulation of theRead MoreHofstede cultural dimension: spain1888 Words   |  8 Pages(Lane at al 2006). Geert Hofstede analyzed in terms of his study a large database of employee values scores collected by IBM between 1967 and 1973. From the results Hofstede developed four dimension models that differentiate cultures according to: Power Distance Index (PDI) - the extent to which the less powerful members of organizations and institutions (like the family) accept and expect that power is distributed unequally. Individualism (IDV) - the one side versus its opposite, collectivismRead MoreStudy Habits2859 Words   |  12 PagesSUBJECT: NURSING EDUCATION SEMINAR ON: DEVLOPMENT OF EFFECTVE STUDY HABIT General Objectives: The students will gain in depth knowledge about various methods of effective learning and practice it during their study time. Specific Objectives: At the end of the seminar the students will be able to, 1) Define learning and study habits 2) Explain the concept of Study skills 3) Describe the Process of study 4) Enlist the Types of learning 5) Develop Effective Study Habits 6) ElaborateRead MoreHigh Fidelity Patient Simulation For Nursing Education6315 Words   |  26 Pagesreliable care to the population it serves. This barrier affects nurses since they gain little clinical skills and experience to deal with various health problems. Despite the literature content that nurses may gain from the classroom, this content alone is not adequate for clinical practice. Therefore, substantial interventions are necessary to improve the clinical experience gained within practice settings. One solution to address this problem has been the integration of high-fidelity simulation [HFS]